Modulation of synapse formation by cyclic adenosine monophosphate.
نویسندگان
چکیده
Synapses between neuroblastoma-hybrid cells and myotubes exhibit a high degree of plasticity. Increase of cyclic adenosine monophosphate (AMP) levels of the hybrid cells for several days results in the appearance of functional voltage-sensitive Ca2+ channels, which are required for evoked secretion of acetylcholine. The results show that cyclic AMP regulates synaptogenesis by regulating the expression of voltage-sensitive Ca2+ channels, and suggest that cyclic AMP affects posttranslational modifications of some glycoproteins and cellular levels of certain proteins.
منابع مشابه
AMPAR α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor CaMKII calcium/calmodulin-dependent protein kinase type II cAMP cyclic adenosine monophosphate CRE cAMP-response element CREB CRE-binding protein CS conditioned stimulus LTD long-term depression LTM long-term memory LTP long-term potentiation MAPKs mitogen-activated protein kinases
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ورودعنوان ژورنال:
- Science
دوره 222 4625 شماره
صفحات -
تاریخ انتشار 1983